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In this latest study, researchers noted that patients with a certain genetic variation experienced more weight loss on a low-fat diet than a low-carb diet.

The gene (TCF7L2 rs7903146) associates with diabetes through GLP-1 secretion, which is more closely tied to fat consumption than carbs. Other genes associate with diabetes through insulin, which is more closely tied to carb consumption than fat.

TCF7L2 rs7903146-macronutrient interaction in obese individuals’ responses to a 10-wk randomized hypoenergetic diet.